Lessons Learned from Landmark Studies in Glaucoma
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https://doi.org/10.56692/upjo.2023110305Keywords:
Disease progression, Intraocular pressure, Primary open angle glaucoma, Visual field.Dimensions Badge
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© UPJO, 2023 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by-nc-sa/4.0/.
Background: Glaucoma is a disease characterized by progressive optic neuropathy that can be caused by a variety of etiologies, including both primary and secondary mechanisms, with the main modifiable risk factor being high intraocular pressure (IOP). Visual field defects, along with structural and functional changes, are typically seen. It is one of the leading causes of blindness worldwide, and as the proportion of those over age 40 increases, so will the prevalence of glaucoma.Abstract
Purpose: This article aims to provide a brief review of the important early glaucoma studies with abundant evidence and thus guide us in our management decisions.
Methods: We reviewed diagnostic criteria used by landmark glaucoma clinical trials, which were prospective, multicenter, masked, randomized control trials. We included trials that were concerned mainly with open-angle glaucoma.
Result and conclusion: Landmark studies have demonstrated that lowering IOP is of benefit in preventing the onset of glaucoma in ocular hypertension and in reducing disease progression in eyes with primary open-angle glaucoma (POAG) but do not suggest that the degree of protection is related to the degree of IOP reduction.
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