Role of Eye Platelet-Rich Plasma in the Treatment of Ocular Surface Disorders

Abstract

The use of blood derivatives represents an alternative therapeutic approach that is gaining interest in regenerative medicine due
to its potential to stimulate and accelerate tissue healing. Platelet-rich plasma is the highly concentrated form of autologous
human platelets in a small amount of plasma which contains important growth factors and plasma proteins that play a significant
role in the wound healing process by epithelial differentiation and collagen bundle organization.
In this article, we aim to provide an update on the current literature regarding the eye platelet-rich plasma, its methods of
preparation, physiological and biochemical properties, its clinical applications, safety and efficacy as compared to other bloodderived products, etc. In ophthalmology, this product is being used in the management of symptomatic dry eyes, corneal ulcers,
periocular chemical and thermal burns, idiopathic macular hole, skin rejuvenation post blepharoplasties and more recently
actinic elastosis in the lower eyelid regions. The role of eye platelet-rich plasma in ocular surface disorders has been sparsely
studied in literature with more studies and reports on the application of autologous and allogeneic serum eye drops therefore, it
becomes very important to update ourselves with more studies in this topic to prove the efficiency of this blood-derived product.